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VITAMIN D

Meta-analysis fails to find association of vitamin D with ART outcome

Despite some earlier evidence to the contrary and ongoing debate, a new meta-analysis has concluded that serum vitamin D levels have no influence on ART outcomes in terms of pregnancy, live birth and miscarriage rates. But the debate goes on.

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BMI

Both partners’ BMI in couples hoping to conceive has an effect on time to pregnancy

While evidence is strong that high BMI has an adverse effect on female fertility, little is known of how ‘abnormal’ pre-pregnancy BMIs in women and men are associated with time to pregnancy. A large cohort study from China suggests that management of couples’ pre-pregnancy BMI might improve their fertility.

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COVID-19

ESHRE updates its fertility clinic guidance for second wave of infections

New guidance from ESHRE for maintaining safe fertility services during a dramatic spike in COVID-19 case numbers has realigned mitigation steps according to local levels of infection.

Guideline Female Fertility Preservationread

ESHRE GUIDELINES

A decade of ESHRE evidence-based guidelines

It is now ten years since ESHRE embarked on its formal guideline programme. During that time six evidence-based guidelines have been published – the latest in female fertility preservation – and ten good practice recommendations. We talk to research specialist Nathalie Vermeulen about ESHRE’s progress so far.

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CAMPUS: IMPLANTATION 2

How the IVF lab influences the chance of implantation after embryo transfer

A well attended online Campus meeting in November considered implantation from clinical, embryological and endometrial perspectives, but also focused on the day-to-day working of the IVF lab.

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CAMPUS: UTERINE SURGERY

Even radical reproductive surgery need not mean the end of fertility and motherhood

An online Campus meeting held in October considered the outcomes of uterine transplantation for fertility restoration and radical surgery to treat genital tract malformations. The conclusions were positive but cautious.

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SPERM VIABILITY

Mitochondrial DNA in sperm linked to fertility and pregnancy probability

A cohort study in non-IVF couples trying to get pregnant has found that sperm mitochondrial DNA copy number may be useful as a biomarker of male reproductive health and the likelihood of pregnancy, even in the general population.

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CAMPUS: IMPLANTATION 1

From biology to practice: Transferring a healthy embryo to a receptive uterus

The organisation of an online Campus meeting in November by three ESHRE SIGs – Embryology, Implantation & Early Pregnancy, and Stem Cells – reflected the range and complexity of achieving successful implantation in assisted reproduction. This well attended course of three half-days considered implantation from clinical, hormonal, embryological and endometrial perspectives.

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CAMPUS: UTERINE SURGERY

Uterine environment ‘as important as the embryo’ in affecting implantation and pregnancy

An online Campus meeting held in October reviewed the diagnosis of uterine abnormalities and the minimally invasive surgical - and emerging medical - approaches in their management ahead of fertility treatment.

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IRREGULAR CYCLES

Irregular menstrual cycles linked to premature mortality risk

Irregular and long menstrual cycles in adolescence and adulthood have been associated with a greater risk of premature mortality than regular cycles in a large cohort study. The associations were found strongest for deaths from cardiovascular disease.

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