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COVID-19

ESHRE updates its fertility clinic guidance for second wave of infections

New guidance from ESHRE for maintaining safe fertility services during a dramatic spike in COVID-19 case numbers has realigned mitigation steps according to local levels of infection.

Guideline Female Fertility Preservationread

ESHRE GUIDELINES

A decade of ESHRE evidence-based guidelines

It is now ten years since ESHRE embarked on its formal guideline programme. During that time six evidence-based guidelines have been published – the latest in female fertility preservation – and ten good practice recommendations. We talk to research specialist Nathalie Vermeulen about ESHRE’s progress so far.

egg freezingread

EGG FREEZING

Comparable outcomes from fresh and vitrified sibling oocytes found in large egg donation series

The largest study to compare the viability of vitrified and fresh sibling oocytes has reaffirmed their comparable efficacy, but only when the efficiency of the vitrification procedure – and oocyte loss at warming - are taken into account.

Coffeeread

COFFEE IN PREGNANCY

‘No safe level’ of caffeine consumption for pregnant women and would-be mothers

A review of findings from observational studies and meta-analyses concludes that maternal caffeine consumption is ‘reliably’ associated with several adverse outcomes of pregnancy. Pregnant women advised ‘to avoid caffeine’.

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SPERM VIABILITY

Mitochondrial DNA in sperm linked to fertility and pregnancy probability

A cohort study in non-IVF couples trying to get pregnant has found that sperm mitochondrial DNA copy number may be useful as a biomarker of male reproductive health and the likelihood of pregnancy, even in the general population.

lockdownread

LOCKDOWN ESHRE

A time like no other: ESHRE in the first six months of COVID-19

It was in mid-March this year, in the face of an alarming rise in coronavirus infections and restrictions on travel, that ESHRE cancelled its upcoming Campus meetings. Two weeks later the annual meeting was also cancelled and a week after that, on 2 April, ESHRE’s precautionary statement on fertility services advised that all but essential treatments ‘should not be started’. For ESHRE and the entire fertility sector these were steps never taken before. How did ESHRE cope over the next six months? Could an organisation even as successful as ESHRE continue with its everyday business?

Heritable Human Genome Editingread

GENE EDITING

Gene editing not yet safe or effective enough for human use

A new report from a high-powered commission formed after gene-edited twins were born in China concludes that the editing technologies must be still be proven safe and effective before countries might approve their use in human embryos.

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IRREGULAR CYCLES

Irregular menstrual cycles linked to premature mortality risk

Irregular and long menstrual cycles in adolescence and adulthood have been associated with a greater risk of premature mortality than regular cycles in a large cohort study. The associations were found strongest for deaths from cardiovascular disease.

FoR COVID-19 pregnancyread

STILLBIRTH

Incidence of stillbirth found to rise during pandemic lockdown

Two studies find a sudden increase in the rate of stillbirth and neonatal death, which may, say their authors, be attributed to fewer hospitalisations during periods of lockdown.

Mitochondriaread

MITOCHONDRIAL DNA

New study fails to support mitochondrial DNA in embryos as a biomarker of implantation potential

Study of more than 600 euploid blastocysts finds mitochondrial DNA content does not correlate with female age and is not predictive of reproductive outcomes.

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