FoR COVID-19 pregnancyread

STILLBIRTH

Incidence of stillbirth found to rise during pandemic lockdown

Two studies find a sudden increase in the rate of stillbirth and neonatal death, which may, say their authors, be attributed to fewer hospitalisations during periods of lockdown.

Mitochondriaread

MITOCHONDRIAL DNA

New study fails to support mitochondrial DNA in embryos as a biomarker of implantation potential

Study of more than 600 euploid blastocysts finds mitochondrial DNA content does not correlate with female age and is not predictive of reproductive outcomes.

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FERTILITY PRESERVATION

Age a significant factor in reproductive outcome of ovarian tissue freezing plus IVF

A little more cohort data helps nudge ovarian tissue freezing for medically indicated fertility preservation from the experimental towards the routine; live birth outcomes significantly affected by patient age.

Populationread

FERTILITY RATES

‘Dramatic’ decline in worldwide total fertility rates predicted

A new complex modelling study forecasts steep declines in total fertility rate by the end of this century, with most of 195 countries analysed unable to maintain their population levels.

egg freezingread

EGG FREEZING

Comparable outcomes from fresh and vitrified sibling oocytes found in large egg donation series

The largest study to compare the viability of vitrified and fresh sibling oocytes has reaffirmed their comparable efficacy, but only when the efficiency of the vitrification procedure – and oocyte loss at warming - are taken into account.

Coffeeread

COFFEE IN PREGNANCY

‘No safe level’ of caffeine consumption for pregnant women and would-be mothers

A review of findings from observational studies and meta-analyses concludes that maternal caffeine consumption is ‘reliably’ associated with several adverse outcomes of pregnancy. Pregnant women advised ‘to avoid caffeine’.

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MOSAICISM

Still no clear views on the transfer of mosaic embryos

Despite reports of successful outcomes and new guidelines, doubts continue to prevail over the acceptability of transferring mosaic embryos.

Heritable Human Genome Editingread

GENE EDITING

Gene editing not yet safe or effective enough for human use

A new report from a high-powered commission formed after gene-edited twins were born in China concludes that the editing technologies must be still be proven safe and effective before countries might approve their use in human embryos.

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PATERNAL AGE

Aneuploidy in embryos found unaffected by increasing paternal age

A study testing aneuploidy in more than 3000 embryos derived from young egg donors and male partners whose ages extended beyond 50 years has failed to find any correlation between the prevalence of aneuploidy and paternal age.

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OHSS

Rates of OHSS in assisted reproduction continue to fall

A new cohort study from a national US database confirms that a lower risk of OHSS is associated with increasing use of GnRH antagonists and agonist trigger and a freeze-all approach to avoid immediate pregnancy.

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