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REGISTRY RESULTS AUSTRALIA

Multiple birth rate in latest Australia/New Zealand registry data falls to all-time low

Annual multiple birth rate fell to 2.9% in 2019, with an elective single embryo transfer rate of almost 92%. The results, when seen alongside a continuing increase in LBR in fresh and frozen cycles, were described as ‘unprecedented’.

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CAMPUS: FERTILITY PRESERVATION

At the crossroads of reproductive and regenerative medicine: new opportunities for preserving and restoring fertility

A September ESHRE Campus workshop organised by the SIGs Fertility Preservation and Stem Cells featured current and emerging approaches for fertility preservation, including oocyte in vitro maturation, cell therapy, reproductive tissue engineering and organ-on-chip approaches. Mina Popovic and Christiani Amorim from the SIG Stem Cells report from the two-day programme.

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ELECTIVE EGG FREEZING

Patient age is the unequivocal determinant of success in social egg freezing

The first study to report on a ‘national landscape’ of elective fertility preservation – based on SART data in the USA - finds that most eggs ‘remain frozen’ despite a steady uptake in the number of cryopreservation cycles.

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BARIATRIC SURGERY

New meta-analysis on the need for personalised periconception care after bariatric surgery

Bariatric surgery increases fertility rates but study conclusions recommend postponing pregnancy until weight loss has stabilised and vitamin status normalised. Regular monitoring of vitamin status and vitamin supplementation is thus also recommended.

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GUIDELINE: VIRAL INFECTION IN ART

ESHRE guideline on viral infection in ART puts emphasis on cutting risk of transmission

New guideline presents evidence on assisted reproduction in cases of six prevalent viruses - Hepatitis B (HBV), Hepatitis C (HCV), HIV, Human T-cell lymphotropic virus (HTLV I/II), Zika and HPV – with recommendations on virus transmission and prevention, and on factors affecting reproductive outcomes in couples with or without fertility problems.

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MALE FERTILITY PRESERVATION

Fatherhood increasingly likely for young men diagnosed with and treated for cancer

A new registry study from Denmark covering 40 years of data shows that, while rates of fatherhood are increasing for men with cancer, the chances are much lower than for men in the general population – and particularly low when diagnosed in young boys and adolescents.

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COVID VACCINATION UPDATE

COVID-19 vaccination advice upgraded yet again for those pregnant or planning pregnancy

With studies continuing to find no detrimental reproductive or pregnancy effects of COVID-19 vaccination, agencies and investigators have stepped up their recommendations in its favour.

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COVID-19 IN ART

‘Reassuring’ data from ESHRE’s COVID-19 ART pregnancy registry

Findings from the first analysis of ESHRE’s registry of COVID-19-affected ART pregnancies ‘offer reassurance’ that outcomes are similar to those found in spontaneous pregnancies.

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MEASURING SUCCESS

A measure of success has been proposed which includes effectiveness, acceptability and safety

A new proposal for measuring ‘success’ in IVF aims to meet a patient’s predetermined chance of success and expectations at the lowest possible risk, costs, time and treatment burden; clinical outcome is best measured as cumulative live birth rate per intention to treat.

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PRETERM BIRTH

The vaginal environment in early pregnancy offers warning signs of preterm birth

A new study suggests that mothers at risk of premature birth may be identified far sooner in pregnancy than current tests allow by identifying specific bacteria and metabolites in their cervico-vaginal fluid.

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