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FERTILITY PRESERVATION

No guarantee of success for preserving fertility ahead of treatment for benign conditions

A September Campus meeting organised by the SIG Fertility Preservation reviewed approaches to fertility preservation in benign conditions such as endometriosis, POI and haematological diseases.

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ENDOMETRIOSIS

Still no panacea in the treatment of endometriosis; a multidisciplinary approach remains essential

A September Campus meeting organised by the SIG Nursing and Midwifery reviewed current approaches to endometriosis management but heard that care must depend on a multidisciplinary approach in which nurses and midwives are an essential part.

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CANCER RISK

A higher risk of cancer found in children born after frozen-thawed embryo transfer

A large cohort study from the Nordic countries has found that children born after FET had a higher risk of childhood cancer than children born after fresh embryo transfer and spontaneous conception, while no increased risk was found after any form of ART collectively. The authors urge caution in interpreting the results.

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CLIMATE CHANGE

Climate change is here, raising the risks for reproductive health

A series of editorials and studies in the August issue of Fertility & Sterility describe climate change as a major risk factor for reproductive health. Erratic weather and its consequences - air pollution, wildfires, heat stress, floods, and vector-borne diseases – will have an impact on male and female fertility.

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FERTILITY PRESERVATION

When, how and if to offer fertility preservation in benign conditions

Following a September Campus meeting organised by the SIG Fertility Preservation, Focus on Reproduction spoke to the SIG’s co-ordinator Professor Michaël Grynberg about indications, patient suitability and limitations to success in a range of conditions, including endometriosis, POI and pre-surgery.

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GROWTH HORMONE

Growth hormone in IVF: the endometrial effect

A new meta-analysis finds that treatment with growth hormone in IVF is associated with improved reproductive outcomes largely mediated by an effect on endometrial function, especially in poor responders.

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TIME LAPSE

Time-lapse technology and the ploidy status of embryos

Although a substantial new meta-analysis has defined three morphokinetic variables significantly associated with aneuploidy, the review authors conclude that more evidence is needed before time-lapse and machine learning are ready for embryo assessment and selection of euploid embryos.

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SYNTHETIC EMBRYOS

No eggs, no sperm, no uterus: extending the boundaries of mammalian development in vitro

Two recently published papers have described experiments in which mouse embryo models were developed from pluripotent stem cells. Mina Popovic and Susana Chuva de Sousa Lopes from ESHRE’s SIG Stem Cells report.

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SEASONALITY

Live birth rates in fresh IVF no higher after summer treatment than at other times

A large Swedish registry study has failed to find any link between ART carried out in the summer months – when vitamin D levels may be highest – and improved birth rates. Once again seasonal variability appears to have no impact on IVF success.

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PROGESTERONE SUPPLEMENTATION

Benefits of progesterone supplementation in natural cycle FET confirmed in new trial

At a time when the number of frozen embryo transfers is increasing worldwide, a new RCT in unmedicated cycle FETs found a statistically higher birth rate when supplemented in the luteal phase with vaginal progesterone; such support, write the authors, ‘should be considered for introduction in clinical routine’.

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