‘Over evaluated, over diagnosed, and over treated’: a new ‘consensus’ on RIF

Draft recommendations from ESHRE on recurrent implantation failure advise that the evidence available ‘does not permit robust conclusions to be drawn’. This and a new ‘consensus’ just published conclude that true RIF is uncommon, affecting fewer than 5% of the ART population.



Small RCT finds DuoStim of no birth-rate benefit in predicted poor responders

Despite promising results in observational studies, a small RCT in patients with a predicted poor ovarian response has found comparable rates of live birth in those randomised to a same-cycle dual stimulation protocol as in those randomised to conventional stimulation in two consecutive cycles.



From mice to men: will a proof-of-concept male contraceptive progress to primetime?

A widely reported preclinical study has found that a single dose of a drug which switches off a signalling protein can immobilise mouse sperm for up to two and half hours. Researchers said it showed promise as an easy-to-use on-demand contraceptive for men.



Cohort study reaffirms link between endometriosis and pregnancy loss

A large Danish population study of almost 30,000 women diagnosed with endometriosis between 1977 and 2017 (and matched with 300,000 controls) has found an association with pregnancy loss and recurrent pregnancy loss, but also that the association strengthened with the increasing number of miscarriages.



Cost of IVF in low- and middle-income countries beyond the reach of most

Despite isolated efforts to simplify IVF in poor-resource countries, costs of treatment can be as much as 200% of a country’s GDP per capita. Such costs represent ‘significant inequalities’ of access to ART in low-income countries and a denial of access for most people.



Another trial fails to find benefit of progesterone in preventing threatened pregnancy loss

Following a large multicentre trial and meta-analyses over the past few years, another RCT has found no benefit from vaginal progesterone in preventing pregnancy loss in women with vaginal bleeding and pain in the first trimester. ESHRE updates its guideline on recurrent pregnancy loss.



A new classification of ovulatory disorders for making ‘a precise diagnosis’

Following many years of classifying ovulatory disorders into groups largely based on hormone levels, FIGO has now presented a new classification system based on anatomical origin (hypothalamus, pituitary and ovarian), and with PCOS now defined in a separate fourth group.



Men with physically demanding jobs found to have higher sperm concentration and total sperm count

A study based on self-reported answers to a questionnaire cross-referred to semen samples and hormone measurements has found that physically demanding jobs and rotating or evening shift working may be associated with higher testicular function in men as seen by higher sperm concentrations and counts as well as higher serum testosterone and estradiol levels.


ESHRE 2023

Precongress courses at ESHRE23 characterised by practicality and topicality

Nineteen PCCs have been scheduled for this year’s annual meeting, 13 organised by ESHRE’s Special Interest Groups covering a wide range of themes and presenting speakers of international renown. A record number of abstracts have been received for the main scientific programme.



New guideline on fertility sparing in endometrial cancer introduced at Campus meeting

Although most cases of endometrial cancer are diagnosed in postmenopausal women, there is a minority for whom pregnancy remains welcome and possible. This February Campus meeting explored the treatment of endometrial cancer with fertility preservation in mind, with many speakers members of the new guideline’s development group.

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