EUROPEAN IVF MONITORING
With 1 million+ euro of funding, the EuMAR project (European monitoring of Medically Assisted Reproduction) aims to develop a prospective cycle-by-cycle platform for the collection of ART data; this hopes to conform with proposals for the revised tissue and cell directives and raise the level of quality assurance, surveillance and vigilance in European reproductive medicine.
CAMPUS: SIG EMBRYOLOGY
During an extremely well attended Campus meeting in May on embryo selection in IVF the reproductive geneticist Elpida Fragouli gave two presentations on PGT-A, one on emerging non-invasive methods and a second on the wider application of aneuploidy testing in embryos. Elpida, basic science officer of the SIG, spoke to ESHRE about both these subjects, which continue to raise unresolved questions.
A 20-year study has found that parenting and child adjustment did not differ among children from gamete-donation and natural conception families from ages 3 to 20. The absence of a biological link between children and their parents appears not to affect mother–child relationships or psychological adjustment in young adulthood.
A further analysis from the ongoing Nurses’ Health Study, which last year suggested a link between irregular menstrual cycles and (obesity-related) endometrial and colorectal cancers, now extends the association to infertility itself.
A prospective study comparing outcomes in PGT-A and conventional IVF blastocysts has found that those with negative DNA amplification in blastocoel fluid had a much higher LBR per transfer than blastocysts with positive amplification. The DNA amplification of blastocoel fluid could become an ‘easy and cost-effective tool’ in embryo selection, say the authors.
ART BIRTH OUTCOMES
A study cross-linking Swedish registries has compared adverse birth outcomes in ART-treated lesbian couples (thus without an infertility indication) with those of heterosexual couples conceiving naturally and with ART; the lesbian pregnancies had ‘more favourable’ birth outcomes.
In March ESHRE’s SIG Psychology & Counselling hosted a well-attended introductory training course on infertility counselling. High on the agenda were newly introduced digital support interventions. Mariana Sousa Leite, Junior Deputy of the SIG, reports.
CAMPUS: EMBRYO SELECTION
A fully booked Campus meeting on embryo selection reviewed a catalogue of emerging concepts and developments in embryo selection - notably covering PGT-A, time-lapse and artificial intelligence - but behind the presentations lay an agreement that morphological assessment still sets the gold standard.
BODY WEIGHT IN PCOS
An integrated meta-analysis and gene variant study demonstrates for the first time the ‘critical role’ of excess childhood/adolescent adiposity on the pathophysiology of adult PCOS. Effective weight maintenance, even from the early years, is likely to reduce the risk.
The first comprehensive meta-analysis of PGT-A for its effect in older ART patients confirms a decline in LBR but finds that the decline occurs independently of the embryo’s ploidy status.
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